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Other in vitro research—tests conducted using cells in test tubes rather than inside patients—also indicated the potential efficacy of chloroquine. According to Raoult, the effect of both chloroquine and its derivative hydroxychloroquine is probably the same since the mechanism of action of these two closely-related molecules is identical, he noted in a study published in the International Journal of Antimicrobial Agents. For around a decade, studies have reported potential anti-viral properties of these two substances against flu and SARS—another form of coronavirus.

With regards to hydroxychloroquine specifically, more encouraging in vitro results emerged in a paper published on March 9, in the journal Clinical Infectious Diseases. However, the data was not deemed sufficient by infectious disease experts to recommend the compound as a treatment yet, Medscape reported. It is a drug I find rather fascinating, that has been used for decades," he told Medscape.

In any case, the adverse effects of this compound are not dangerous. Thomas Papo from Bichat Hospital, the University of Paris, noted that because the drug has been used for decades, we know lots about it.

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This drug is remarkably well tolerated and we give it to all patients with lupus for example , including in pregnant women. The main complication retinal toxicity is rare and does not last beyond 5 years of continuous use," he told Medscape. Because the safety of hydroxychloroquine is well-established this should theoretically make it relatively easy to accelerate development into a treatment for COVID if clinical trials are successful, especially given that it is cheap and not difficult to manufacture. Scientists will continue to conduct trials of the substance in the immediate future.

For example, Raoult's trial in Marseille is being extended.

Trump backs COVID hydroxychloroquine and azithromycin therapy with weak science

Nevertheless, some experts such as Gilles Pialoux, an infectious disease specialist at Tenon Hospital, France, are more cautious over hydroxychloroquine, noting that there are potentially more promising treatments available, such as a drug called remdesivir. According to a paper published in The New England Journal of Medicine , which involved patients—99 of whom were given Kaletra—at a hospital in Wuhan, China, the treatment produced no observable benefit beyond standard care procedures. However, the researchers note that more research is needed to determine whether or not this treatment is effective against the virus.

So they tried this?? Please keep on being a voice for reason. People appear to have very uninformed ideas about the difference between an attractive molecule and a medicine.

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Most, the majority, almost all hypothetical treatments wind up not working. Some brilliant guy with shaggy hair who just thinks up a miracle drug is only found in the movies. In real world, it is done by teams of shaggy technicians with brilliant hair, working under the inspired leadership of project manager — who is covering his butt, servile and paranoid in equal measure.

The dropouts in the treatment arm are a major problem for interpreting the data. So I would be extremely cautious on the hydroxychloroquine data. At the moment it looks ambiguous to me. Also it would be much more interesting to see the actual viral titers in the patients rather than percentage of patients as the endpoint. Reasons are as follows: three patients were transferred to intensive care unit, including one transferred on day2 post-inclusion who was PCR-positive on day1, one transferred on day3 post-inclusion who was PCR-positive on days and one transferred on day4 post-inclusion who was PCR positive on day1 and day3; one patient died on day3 post inclusion and was PCR-negative on day2; one patient decided to leave the hospital on day3 post-inclusion and was PCR-negative on days; finally, one patient stopped the treatment on day3 post-inclusion because of nausea and was PCR-positive on days It seems disconcerting that that 4 people in the treatment group dropped out due to progression to ICU or death, while none of that happened in the control group.

But the people in the treatment group were older Hydroxychloroquine is also used to suppress autophagy. Is that help WRT fighting a viral infection?

Coronavirus & Ibuprofen: Dr. Alexea Gaffney-Adams Clears Up Dangers, Facts, and Fiction - NowThis

Or would combination therapy with something that promotes autophagy, such as Ambroxol, be useful? Azithromycin also blocks autophagy! Looking at the Gautret paper. Am I the only one that is far more interested for Pre exposure prophylaxis? This would be a gamechanger since it transforms the disease completely. As long as you take your meds you cannot get sick. Low doses of AZ are routinely given to asthmatics for preventing exacerbations. I would like to see if mefloquine works for this — it would be an ideal pre-exposure prophylaxis agent — mg once or twice weekly maybe with azithromycin mg twice weekly the PK for mefloquine is great for this type of prescription — controlled trial in emergency medical workers would be easy to set up and fast to get results — assuming these anti malaria meds for for this virus.

Do you know of any trials planned on these targets? Azithromycin is a macrolide antibiotic with well-described anti-inflammatory properties which can be attributed, at least partially, to its action on macrophages. Most of the anti-inflammatory effect documented in studies of azithromycin is in vitro. We need to look harder at the three deaths in elderly patients receiving azithromycin in the Rouault study to affirm or rule out cytokine storm.

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Agree someone independent should replicate the French hydroxychloroquine results which follow earlier Chinese testing as well in a larger, much better trial. Italian group claims they cannot find any record of the chloroquine results in the clinical trial registry. We sought for evidence of such data in the trial registries we reviewed and found none.

Zinc should be looked at more. Zinc is known to inhibit the viral RNA polymerase and the chloroquine acts as a zinc ionophore to rapidly transport zinc ions through cell membranes into the cytoplasm where they are needed. For most normal healthy people, there is no need for ionophores, our natural zinc transporter proteins are good enough for the job. Keeping zinc levels well maintained by zinc supplementation will indeed help prevent the rapid multiplying of viruses.

Many people have seen the effects of zinc lozenges to beat the common cold. Thank god for glowing testimonials for sketchy cures made by people named after the purported cures.

Thank god for glowing trolling done by people named after a math variable… What a contribution! It is perfectly reasonable to propose that zinc and chloroquine could have synergistic effects. Synergy does not require individual efficacy.


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Considering the properties and MoA at work it is something at least worth looking into. At least one animal study has found zero effect of dietary zinc on CoV etiology. Different one, though.

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Jones is already pushing zinc aggressively, probably because he has pallets of a slow moving supplement that contains a bit of zinc gathering dust in his warehouse. Azi is a pretty obvious choice to co-dose. Chalk up another spectacularly bad call for Vallance, Witty and Slaoui. JP would have known better. Clinical evidence also does not support the use of steroids for Covid Lancet 7 Feb Steroids have many many effects, but a primary one is anti-inflammatory. Hence, as others as noted, we need to be careful about recommending treatments without good data, particularly when available data suggests the treatment could make patients worse.

So at best this small non-random open label study means nothing more than more research is needed …. There is a paper doing the rounds about a soluble derivative of aspirin with in vitro activity against SARS2 and potential for inhalation administration when they say potential, note the IV dose would be lethal…. It is a Furin protease, and has been used to successfully treat feline infectious peritonitis, which is caused by the coronavirus FeCoV.

Is carrimycin a man made macrolide? Obviously the combination of QT prolonging drugs sounds dangerous. The french study, right or wrong, suggests that azithromycin might be the bigger addition. Would love to see study on azithromycin alone, as this drug is generally well tolerated and would not produce the combination QT side effect. Scary to see mass use of azithromycin without significant proof, especially with this drugs tendency to promote resistance. HCQ has a 22 day half life in the average human, so the french study would be gradually building up a dose, which eventually is therapeutic.

A lot of this puzzle has to be in the loading dose that is eventually needed if the effect is happening. Anyone know if people on high dose long-term HCQ in the RA or Lupus community are mysteriously not getting sick despite being immunocompromised? In a phone interview on Tuesday, Dahly said that even if the methodology had been more rigorous, a single study should not have caused such dramatic policy actions, nor was it the original author's intention.

But in the days before they published, concerns were raised by scientists and other observers about just how much confidence should be placed in the experimental therapy. Asked if there was any evidence the drugs could be used as a prophylaxis, Fauci was unequivocal. What's more, people rushing to pharmacies to buy these drugs endangers those who need them to treat conditions such as lupus.

Dawn Butterfield the owner of West Cocoa Pharmacy in Brevard County, Florida said her staff received at least 15 calls representing dozens of patients over the past few days.